Rainer Machauer: search on Z-Library

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1

Synthesis of Lipidated eNOS Peptides by Combining Enzymatic, Noble Metal- and Acid-Mediated Protecting Group Techniques with Solid Phase Peptide Synthesis and Fragment Condensation in Solution

Rainer Machauer, Herbert Waldmann

Journal:

Chemistry - A European Journal

Year:

2001

Language:

english

File:

PDF, 313 KB

english, 2001

2

Structure-based design and synthesis of macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors

Rainer Machauer, Siem Veenstra, Jean-Michel Rondeau, Marina Tintelnot-Blomley, Claudia Betschart, Ulf Neumann, Paolo Paganetti

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 869 KB

english, 2009

3

Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides

Staufenbiel, Matthias, Desrayaud, Sandrine, Neumann, Ulf, Rueeger, Heinrich, Lueoend, Rainer, Rogel, Olivier, Rondeau, Jean-Michel, Möbitz, Henrik, Machauer, Rainer, Jacobson, Laura

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 3.33 MB

english, 2012

4

Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach

Chen, Chao, Zhu, Hugh, Stauffer, Frédéric, Caravatti, Giorgio, Vollmer, Susanne, Machauer, Rainer, Holzer, Philipp, Möbitz, Henrik, Scheufler, Clemens, Klumpp, Martin, Tiedt, Ralph, Beyer, Kim S., Cal

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1014 KB

english, 2016

5

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich,

Journal:

EMBO Molecular Medicine

Year:

2018

Language:

english

File:

PDF, 2.12 MB

english, 2018

6

ChemInform Abstract: Synthesis of Lipidated eNOS Peptides by Combining Enzymatic, Noble Metal- and Acid-Mediated Protecting Group Techniques with Solid Phase Peptide Synthesis and Fragment Condensation in Solution.

Rainer Machauer, Herbert Waldmann

Journal:

Year:

2002

File:

PDF, 25 KB

2002

7

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

Neumann, Ulf, Rueeger, Heinrich, Machauer, Rainer, Veenstra, Siem Jacob, Lueoend, Rainer M., Tintelnot-Blomley, Marina, Laue, Grit, Beltz, Karen, Vogg, Barbara, Schmid, Peter, Frieauff, Wilfried, Shim

Journal:

Molecular Neurodegeneration

Year:

2015

Language:

english

File:

PDF, 3.01 MB

english, 2015

8

Synthese des N-terminalen N-myristoylierten und S-palmitoylierten Undetrigintapeptids der endothelialen NO-Synthase

Rainer Machauer, Herbert Waldmann

Journal:

Angewandte Chemie

Year:

2000

Language:

german

File:

PDF, 104 KB

german, 2000

9

THE BACE INHIBITOR NB-360 HAS EXCELLENT BRAIN PENETRATION AND EFFICACY ON AMYLOID-B LOAD IN ANIMAL MODELS

Neumann, Ulf, Rueeger, Heinrich, Machauer, Rainer, Veenstra, Siem, Lueoend, Rainer, Tintelnot-Blomley, Marina, Laue, Grit, Beltz, Karen, Vogg, Barbara, Shimshek, Derya, Frieauff, Wilfried, Schmid, Pet

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 170 KB

english, 2014

10

The BACE inhibitor NB-360 in preclinical models: From β-amyloid reduction to downstream disease-relevant effects

Neumann, Ulf, Machauer, Rainer, Shimshek, Derya R.

Journal:

British Journal of Pharmacology

Year:

2019

Language:

english

File:

PDF, 1.02 MB

english, 2019

11

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides

Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem Jacob, Jacobson, Laura Helen, Staufenbiel, Matthias, Desrayaud, Sandrine, Rondeau, Jean-Michel, Möbitz, Henrik, Neumann, Ulf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.90 MB

english, 2013

12

Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application

Andreas Lerchner, Rainer Machauer, Claudia Betschart, Siem Veenstra, Heinrich Rueeger, Clive McCarthy, Marina Tintelnot-Blomley, Anne-Lise Jaton, Sabine Rabe, Sandrine Desrayaud, Albert Enz, Matthias

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 369 KB

english, 2010

13

Synthesis of the N-Terminal N-Myristoylated and S-Palmitoylated Undetrigintapeptide of Endothelial NO-Synthase

Rainer Machauer, Herbert Waldmann

Journal:

Angewandte Chemie International Edition

Year:

2000

Language:

english

File:

PDF, 118 KB

english, 2000

14

Macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors with activity in vivo

Rainer Machauer, Kurt Laumen, Siem Veenstra, Jean-Michel Rondeau, Marina Tintelnot-Blomley, Claudia Betschart, Anne-Lise Jaton, Sandrine Desrayaud, Matthias Staufenbiel, Sabine Rabe, Paolo Paganetti,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 671 KB

english, 2009

15

Synthesis of cis-2,5-Disubstituted Pyrrolidines via Diastereoselective Reduction of N-Acyl Iminium Ions.

Alexander C. Rudolph, Rainer Machauer, Stephen F. Martin

Journal:

Year:

2004

File:

PDF, 36 KB

2004

16

Corrigendum to “Structure-based design and synthesis of macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 1361–1365]

Rainer Machauer, Siem Veenstra, Jean-Michel Rondeau, Marina Tintelnot-Blomley, Claudia Betschart, Ulf Neumann, Paolo Paganetti

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 102 KB

english, 2009

17

Synthesis of cis-2,5-disubstituted pyrrolidines via diastereoselective reduction of N-acyl iminium ions

Alexander C Rudolph, Rainer Machauer, Stephen F Martin

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

18

Enantioselective synthesis of (+)-anatoxin-a via enyne metathesis

Jehrod B. Brenneman, Rainer Machauer, Stephen F. Martin

Journal:

Year:

2004

Language:

english

File:

PDF, 297 KB

english, 2004

19

Enantioselective Synthesis of (+)-Anatoxin-a via Enyne Metathesis.

Jehrod B. Brenneman, Rainer Machauer, Stephen F. Martin

Journal:

Year:

2004

Language:

english

File:

PDF, 29 KB

english, 2004

20

Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach

Möbitz, Henrik, Machauer, Rainer, Holzer, Philipp, Vaupel, Andrea, Stauffer, Frédéric, Ragot, Christian, Caravatti, Giorgio, Scheufler, Clemens, Fernandez, Cesar, Hommel, Ulrich, Tiedt, Ralph, Beyer,

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 943 KB

english, 2017

21

Discovery and structural characterization of ATP-site ligands for the wild-type and V617F-mutant JAK2 pseudokinase domain

McNally, Randall, Li, Qing, Li, Kunhua, Dekker, Carien, Vangrevelinghe, Eric, Jones, Matthew, Chene, Patrick, Machauer, Rainer, Radimerski, Thomas, Eck, Michael J.

Journal:

ACS Chemical Biology

Year:

2019

Language:

english

File:

PDF, 840 KB

english, 2019

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